2007;62(3):202-206. Hum.Nutr.Clin.Nutr. Vitamin C might decrease how quickly the body gets rid of salsalate. Effect of vitamin C on histamine bronchial responsiveness of patients with allergic rhinitis. Inui, S. and Itami, S. Perifollicular pigmentation is the first target for topical vitamin C derivative ascorbyl 2-phosphate 6-palmitate (APPS): randomized, single-blinded, placebo-controlled study. J Cosmet Dermatol 2020;19(3):671-6. doi: 10.1111/jocd.13305. Eur.J Clin.Nutr 1990;44(2):143-150. View abstract. Abdollahzad, H., Eghtesadi, S., Nourmohammadi, I., Khadem-Ansari, M., Nejad-Gashti, H., and Esmaillzadeh, A. Am.J Clin.Nutr 1975;28(9):973-976. Kennedy M, Bruninga K, Mutlu EA, et al. Linde K, Barrett B, Wolkart K, et al. Cureus 2021;13(11):e19902. View abstract. El Attar Y, Doghaim N, El Far N, El Hedody S, Hawwam SA. B. Jain SK, Dar MY, Kumar S, Yadav A, Kearns SR. Role of anti-oxidant (vitamin-C) in post-operative pain relief in foot and ankle trauma surgery: A prospective randomized trial. There isn't a gluten intolerance test. Preterm birth. Taking vitamin C by mouth, alone or with other supplements, during pregnancy does not reduce the chance of having a stillbirth. Neurology 2000;54:1265-72. View abstract. Vitamin C supplementation in relation to inflammation in individuals with atrophic gastritis: a randomised controlled trial in Japan. J Am Acad Dermatol 2000;43(4):656-663. Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Bennett, D. A., Aggarwal, N., Wilson, R. S., and Scherr, P. A. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. Tee, E. S., Kandiah, M., Awin, N., Chong, S. M., Satgunasingam, N., Kamarudin, L., Milani, S., Dugdale, A. E., and Viteri, F. E. School-administered weekly iron-folate supplements improve hemoglobin and ferritin concentrations in Malaysian adolescent girls. Br J Pharmacol 2004;142(3):567-75. Schwartz J, Weiss ST. 2004;40(1):40-46. 2013;70(8):981-7. Kidney Int 2003;64:1531-2. Am J Epidemiol 1998;148:204-14. Influence of some dietary constituents on aluminum absorption and retention in rats. View abstract. BMC.Geriatr 2011;11:69. View abstract. Ann Intern Med 1999;130:963-70. 1990;44(4):209-212. Nakajima M, Kojiro M, Aso S, et al. Vitamin C deficiency is relatively rare in developed countries but still affects more than 1 in 20 people. Colon cancer, rectal cancer. Am.J Respir.Crit Care Med 2000;161(3 Pt 1):790-795. Pediatr.Allergy Immunol. 2005;24(6):979-987. Coombes, J. S. and Fassett, R. G. Antioxidant therapy in hemodialysis patients: a systematic review. Rattanawiwatpong P, Wanitphakdeedecha R, Bumrungpert A, Maiprasert M. Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial. J.Natl.Cancer Inst. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Effects of Panax ginseng extract in patients with fibromyalgia: a 12-week, randomized, double-blind, placebo-controlled trial. Metabolism of ascorbic acid (vitamin C) in subjects infected with common cold viruses. 2013;109(6):1089-95. Nutr Cancer 2002;42(1):25-32. Rev Bras Psiquiatr 2013;35(1):21-8. Huang, H. Y., Helzlsouer, K. J., and Appel, L. J. Effects of a-cyclodextrin on cholesterol control and hydrolyzed ginseng extract on glycemic control in people with prediabetes: a randomized clinical trial. Losonczy KG, Harris TB, Havlik RJ. Effect of dietary eggs and ascorbic acid on plasma lipid and lipoprotein cholesterol levels in healthy young men. Am J Clin Nutr 1999;69:261-6. Shamseer, L., Adams, D., Brown, N., Johnson, J. Accessed Oct. 11, 2020. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Vitamin E in the primary prevention of cardiovascular disease and cancer: The Women's Health Study: A randomized controlled trial. Clin Investig 1993;71:3-6. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. Symptoms of egg sensitivities, and food sensitivities in general, can vary from person to person. Cochrane Database Syst Rev 2005;(1):CD001782. View abstract. WebMD does not provide medical advice, diagnosis or treatment. Cancer Control 2000;7(3):288-296. An allergic reaction to egg products is usually more serious than an egg intolerance or sensitivity [2]. Lee NA, Reasner CA. View abstract. View abstract. Tzonou, A., Lipworth, L., Kalandidi, A., Trichopoulou, A., Gamatsi, I., Hsieh, C. C., Notara, V., and Trichopoulos, D. Dietary factors and the risk of endometrial cancer: a case--control study in Greece. View abstract. A double-blind, vehicle-controlled clinical trial. Diabetes Care 1991;14(11):1050-1056. Cook, N. R., Albert, C. M., Gaziano, J. M., Zaharris, E., MacFadyen, J., Danielson, E., Buring, J. E., and Manson, J. E. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. N.Engl.J Med. There's some evidence that vitamin C can help protect you from illness such as pneumonia and bladder infections. Zureik, M., Galan, P., Bertrais, S., Mennen, L., Czernichow, S., Blacher, J., Ducimetiere, P., and Hercberg, S. Effects of long-term daily low-dose supplementation with antioxidant vitamins and minerals on structure and function of large arteries. Ophthalmology. Lonn E, Yusuf S, Dzavik V, et al. Hemila, H. and Chalker, E. Vitamin C for preventing and treating the common cold. Clin.Exp.Allergy 2007;37(1):54-61. Nutritional intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. Circulation 2003;108:1059-63.. View abstract. Eur.J Clin.Nutr 1999;53(2):102-106. View abstract. Uusitupa MI, Kumpulainen JT, Voutilainen E, et al. Skin rashes, hives and eczema are common reactions from a vitamin C allergy. A., and Guymer, R. H. Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. 2007;177(2):639-643. Kim SK, Hahm JR, Kim HS, et al. Some of the best vitamin C foods include kiwi, red and green peppers, black currant, broccoli and kale. Spurious elevation of glucose concentration during administration of high dose of ascorbic acid in a patient with type 2 diabetes on hemodialysis. Oral vitamin C and endothelial function in smokers: short-term improvement, but no sustained beneficial effect. Iron absorption in young Indian women: the interaction of iron status with the influence of tea and ascorbic acid. In this condition, the symptoms include tiredness, anaemia, swollen joints, loose teeth, bleeding gums etc. Giraud DW, Martin HD, Driskell JA. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. Weijl, N. I., Elsendoorn, T. J., Lentjes, E. G., Hopman, G. D., Wipkink-Bakker, A., Zwinderman, A. H., Cleton, F. J., and Osanto, S. Supplementation with antioxidant micronutrients and chemotherapy-induced toxicity in cancer patients treated with cisplatin-based chemotherapy: a randomised, double-blind, placebo-controlled study. Cancer Epidemiol Biomarkers Prev 1994;3:161-6. Ear Nose Throat J 1991;70:54-55. Health Technol.Assess. Resp Med 2011;105:165-76. Daily magnesium supplements improve glucose handling in elderly subjects. Since vitamin C has several jobs related to your immune system, it shouldn't surprise you to learn you're more likely to get sick and may have a harder time recovering. Am J Epidemiol 2001:153:157-63. Rubin, R. N., Navon, L., and Cassano, P. A. View abstract. Conditions like anorexia or an overly restrictive diet may also contribute to deficiency. Slow wound healing is one of the more advanced signs of deficiency and typically not seen until someone has been deficient for many months (26, 27). Weight loss. Cochrane Database Syst Rev. Ried K, BinJemain T, Sali A. Small red-blue bruise-like spots on your skin. View abstract. View abstract. ARYA Atheroscler 2021;17(1):1-9. Gandini S, Merzenich H, Robertson C, Boyle P. Meta-analysis of studies on breast cancer risk and diet: the role of fruit and vegetable consumption and the intake of associated micronutrients. Li, J. Y., Taylor, P. R., Li, B., Dawsey, S., Wang, G. Q., Ershow, A. G., Guo, W., Liu, S. F., Yang, C. S., Shen, Q., and . Curr Drug Metab 6-1-2012;13(5):577-598. Gilliland, F. D., Berhane, K. T., Li, Y. F., Gauderman, W. J., McConnell, R., and Peters, J. Phytother Res 1999;13(8):641-4. The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. Am J Epidemiol 2002;156:1002-10.. View abstract. Kaiser, L., Lew, D., Hirschel, B., Auckenthaler, R., Morabia, A., Heald, A., Benedict, P., Terrier, F., Wunderli, W., Matter, L., Germann, D., Voegeli, J., and Stalder, H. Effects of antibiotic treatment in the subset of common-cold patients who have bacteria in nasopharyngeal secretions. 1959;14:288-290. Cancer Causes Control 2011;22(10):1383-1396. View abstract. Circulation 2004;110:2837-42. On the other hand, low levels in your body can cause irritable moods, stress, and negative emotions that affect us. Fowler AA 3rd, Syed AA, Knowlson S, et al. Eur.J Clin.Invest 1997;27(5):387-391. View abstract. View abstract. Kordansky, D. W., Rosenthal, R. R., and Norman, P. S. The effect of vitamin C on antigen-induced bronchospasm. Indian J Med Res 2000;112:206-211. Nutr Cancer. Am J Epidemiol 1996;144:501-11.. View abstract. Ann.Clin Psychiatry 2009;21(4):213-236. Thorax 2008;63(6):507-513. View abstract. Heine H and Norden C. Vitamin C therapy in hyperlipoproteinemia. A. Edgar, D. W., Fish, J. S., Gomez, M., and Wood, F. M. Local and systemic treatments for acute edema after burn injury: a systematic review of the literature. View abstract. The intestinal absorption of vitamin C is regulated by at least one specific dose-dependent, active transporter [ 4 ]. Cesari M, Pahor M, Bartali B, et al. Ophthalmic Physiol Opt. J Am Acad Dermatol 1997;37(2 Pt 1):217-226. However, be careful not to consume vitamin C containing bioflavonoids. Nutr Cancer 2004;49(2):131-138. View abstract. Sahud MA, Cohen RJ. Mochalkin, N. I. Obstet Gynecol. Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomized trial. 2017 Nov;152(5):954-962. Jacobson, J. S., Begg, M. D., Wang, L. W., Wang, Q., Agarwal, M., Norkus, E., Singh, V. N., Young, T. L., Yang, D., and Santella, R. M. Effects of a 6-month vitamin intervention on DNA damage in heavy smokers. View abstract. Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Meyskens, F. L., Jr., Omenn, G. S., Valanis, B., and Williams, J. H., Jr. View abstract. Coronary heart disease in smokers: vitamin C restores coronary microcirculatory function. (Lond) 1942;42(1):1-19. Int J Vitam.Nutr Res 2002;72(6):360-368. Efecto del acido ascorbico sobre los lipidos biliares en pacientes litiasicos. Effect of varying ascorbic acid intakes on copper absorption and ceruloplasmin levels of young men. Acta Genet.Med Gemellol.(Roma.) Neurology 1996;46(5):1270-1274. View abstract. In the body, it acts as an antioxidant, helping to protect cells from the damage caused by free radicals. Vitamin C might decrease how quickly the body gets rid of choline magnesium trisalicylate. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. 2-4-2004;96(3):229-233. Sefton, J., Kligman, A. M., Kopper, S. C., Lue, J. C., and Gibson, J. R. Photodamage pilot study: a double-blind, vehicle-controlled study to assess the efficacy and safety of tazarotene 0.1% gel. 1979;49(2):136-143. Lakartidningen 7-5-1972;69(28):3304-3305. Int J Vitam.Nutr Res 1984;54(4):343-347. JAMA Netw Open 2020 Nov 2;3(11):e2023491. Br J Cancer 1989;59(1):119-125. Blot, W. J., Li, J. Y., Taylor, P. R., Guo, W., Dawsey, S. M., and Li, B. Hum Nutr Appl Nutr 1983;37:136-40. Natural cartilage polysaccharides for the treatment of sun-damaged skin in females: a double-blind comparison of Vivida and Imedeen. Vitamin C keeps skin healthy by protecting it from oxidative damage caused by the sun and exposure to pollutants like cigarette smoke or the ozone (12, 13). Age Ageing 1992;21(6):435-439. Keith, R. E. and Driskell, J. View abstract. Vitamins E and C in the prevention of prostate total cancer in men: the physicians' health study II randomised controlled trial. ", Journal of Current Research in Scientific Medicine: "Antimicrobial activity of Vitamin C demonstrated on uropathogenic Escherichia coli and Klebsiella pneumoniae.". View abstract. N.Engl.J Med 4-8-2010;362(14):1282-1291. Int J Vitam.Nutr Res 1977;47(2):123-134. Devereux, G., Litonjua, A. Zemla, B. Ann.N.Y Acad.Sci 9-30-1992;669:342-344. Groenbaek, K., Friis, H., Hansen, M., Ring-Larsen, H., and Krarup, H. B. Advertising revenue supports our not-for-profit mission. Fried EI, Nesse RM. Effect of inorganic chromium supplementation on glucose tolerance, insulin response, and serum lipids in noninsulin-dependent diabetics. Chest. Eur.Respir.J 2004;24(2):292-297. Decker, K., Dotis, B., Glatzle, D., and Hinselmann, M. Riboflavin status and anaemia in pregnant women. View abstract. Lee HP, Gourley L, Duffy SW, et al. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. Kubo, A. and Corley, D. A. Meta-analysis of antioxidant intake and the risk of esophageal and gastric cardia adenocarcinoma. 1. Oral ginseng formulae for chronic obstructive pulmonary disease: a systematic review. Bjrnsen T, Salvesen S, Berntsen S, et al. Int J Vitam.Nutr Res. What health issues are due to a lack of vitamin C, and what dietary sources can you consume to maintain healthy levels? A. and Mokrow, N. J. Christian, P., West, K. P., Khatry, S. K., LeClerq, S. C., Pradhan, E. K., Katz, J., Shrestha, S. R., and Sommer, A. Kris-Etherton PM, Lichtenstein AH, Howard BV, et al. Collaborative Group of the Primary Prevention Project. World Health Organisation multicentre randomised trial of supplementation with vitamins C and E among pregnant women at high risk for pre-eclampsia in populations of low nutritional status from developing countries. The body breaks down acetaminophen to get rid of it. When the body is deficient in vitamin C, these small blood vessels become fragile and break easily, causing small, bright red spots to appear around the hair follicles. According to a 2018 study on vitamin C in the treatment of allergies, oxidative stress plays a key role in allergic diseases. 2017;3(3):CD011114. Blood 1998;91:2536-46. Anon. Enstrom, J. E., Kanim, L. E., and Breslow, L. The relationship between vitamin C intake, general health practices, and mortality in Alameda County, California. Am.J.Clin.Nutr. View abstract. Osrin, D., Vaidya, A., Shrestha, Y., Baniya, R. B., Manandhar, D. S., Adhikari, R. K., Filteau, S., Tomkins, A., and Costello, A. M. Effects of antenatal multiple micronutrient supplementation on birthweight and gestational duration in Nepal: double-blind, randomised controlled trial. Jelenko, C., III, Wheeler, M. L., Callaway, B. D., Divilio, L. T., Bucklen, K. R., and Holdredge, T. D. Shock and resuscitation. View abstract. Circulation 1999;99:591-5. View abstract. Shu, X. O., Zheng, W., Potischman, N., Brinton, L. A., Hatch, M. C., Gao, Y. T., and Fraumeni, J. F., Jr. A population-based case-control study of dietary factors and endometrial cancer in Shanghai, People's Republic of China. The Linxian cataract studies. Traikovich SS. View abstract. The Top Eight Foods Rich in Vitamin C Vitamin C And Its Hidden Talent In Curing Cancer Oral vitamin intake: Pros & Cons Peanut Allergy Overview: Triggers, Symptoms, and Treatment Fruit Allergy Overview: Causes, Symptoms, Treatments and More Shellfish Allergy Symptoms and Treatments Vitamin C From Food Decreases Risk Of Heart Disease Truth Time . Fractures. Goodwin JS, Sanchez CJ, Thomas P, et al. You can use the study as a second opinion to make health care decisions. A., Hannaford, P. C., Kilonzo, M. M., McNeill, G., Milne, A. C., Ramsay, C. R., Seymour, D. G., Stephen, A. I., and Vale, L. D. Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial. View abstract. Tsubono, Y., Okubo, S., Hayashi, M., Kakizoe, T., and Tsugane, S. A randomized controlled trial for chemoprevention of gastric cancer in high-risk Japanese population; study design, feasibility and protocol modification. Vitamin C is an antioxidant that helps protect your cells against the effects of free radicals molecules produced when your body breaks down food or is exposed to tobacco smoke and radiation from the sun, X-rays or other sources. Anderson TW. Am J Clin Nutr. It is unknown if vitamin C alone decreases the effects of niacin on good cholesterol levels. BMJ 7-6-2002;325(7354):11. View abstract. View abstract. Effect of compound K, a metabolite of ginseng saponin, combined with gamma-ray radiation in human lung cancer cells in vitro and in vivo. View abstract. Buzina, R., Grgic, Z., Jusic, M., Sapunar, J., Milanovic, N., and Brubacher, G. Nutritional status and physical working capacity. Allergy 2006;61(4):438-442. Huang, H. Y., Caballero, B., Chang, S., Alberg, A. J., Semba, R. D., Schneyer, C. R., Wilson, R. F., Cheng, T. Y., Vassy, J., Prokopowicz, G., Barnes, G. J., and Bass, E. B. Q.J.Med. 2020:1-11. View abstract. Kompauer I, Heinrich J, Wolfram G, Linseisen J. Dow, L., Tracey, M., Villar, A., Coggon, D., Margetts, B. M., Campbell, M. J., and Holgate, S. T. Does dietary intake of vitamins C and E influence lung function in older people? Taking too much vitamin C can cause side effects, including: Nausea, vomiting and diarrhea Heartburn Stomach cramps or bloating Fatigue and sleepiness, or sometimes insomnia Headache Skin flushing In some people, oral vitamin C supplements can cause kidney stones, especially when taken in high doses. Gluten- sensitive individuals are usually not likely to develop intestinal lesions. View abstract. Antioxidant activity, ascorbic acid and total phenol of exotic fruits occurring in Brazil. Thornton suggests sodium ascorbyl phosphate or . View abstract. View abstract. 11. Dietary carotenoids and vitamins A, C, and E and risk of breast cancer. View abstract. J Foot Ankle Surg. View abstract. Ahn CM, Hong SJ, Choi SC, Park JH, Kim JS, Lim DS. Crit Care Med 2021;49(12):2121-2130. J Natl Cancer Inst 1996;88:1560-70. The Iowa Women's Health Study. Hypertens.Pregnancy. View abstract. 2008;199(4):433-438. 0000000000000212. Eatemadyboroujeni A, Kargarfard M, Alaei H. Can vitamin C supplementation reverse the effects of exercise training in polluted air on oxidative stress markers? Diabetes Care 1995;18(6):807-816. Diabetes Res Clin.Pract. Canter, P. H., Wider, B., and Ernst, E. The antioxidant vitamins A, C, E and selenium in the treatment of arthritis: a systematic review of randomized clinical trials. A prospective study of diet and adult-onset asthma. Int J Vitam Nutr Res 2003;73(6):411-415. Am J Epidemiol 2001;154:427-33.. View abstract. JAMA 2007;297:842-57. View abstract. View abstract. Ther Apher Dial. ter Riet, G., Kessels, A. G., and Knipschild, P. G. Randomized clinical trial of ascorbic acid in the treatment of pressure ulcers. View abstract. Shaw, R., Woodman, K., Crane, J., Moyes, C., Kennedy, J., and Pearce, N. Risk factors for asthma symptoms in Kawerau children. Am J Clin Nutr 1998;67:722-33.. View abstract. Xie Q, Chen L, Zhao F, et al. The Associations of Dietary Lutein, Zeaxanthin and Fats with Age-Related Macular Degeneration : The Melbourne Collaborative Cohort Study. View abstract. Pazirandeh S, et al. Eur.J Clin.Nutr 1999;53(10):813-817. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission.
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